Pediatric Molecular Neuro-oncology Research

Publications

Last five years:


  1. Ece Sönmez, Shen Yan, Meng-Syuan Lin and Martin Baumgartner. MAP4 kinase-regulated reduced CLSTN1 expression in medulloblastoma is associated with increased invasiveness. Scientific Reports. 2025, 15:946
  2. Alexandre Gries, Karthiga Santhana Kumar, Fabien Kuttler, Özgün Özalp, Veronica Akle, Hanqing Zhang, Michael A Grotzer, Stephan C F Neuhauss, Amin Allalou, Martin Baumgartner. Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context. Neoplasia, 2024 Nov 7:59:101078. doi: 10.1016/j.neo.2024.101078. Online ahead of print.
  3. Afshan S, Kim YG, Mattsson J, Åkerfelt M, Härkönen P, Baumgartner M, Nees M. Targeting the cancer cells and cancer-associated fibroblasts with next-generation FGFR inhibitors in prostate cancer co-culture models. Cancer Med. 2024 Sep;13(18):e70240. doi: 10.1002/cam4.70240. PMID: 39300962; PMCID: PMC11413502.
  4. Santhana Kumar K, Brunner C, Schuster M, Kopp LL, Gries A, Yan S, Jurt S, Moehle K, Bruns D, Grotzer M, Zerbe O, Schneider G, Baumgartner M. Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth. Cell Oncol (Dordr). 2023 Apr;46(2):331-356. doi: 10.1007/s13402-022-00753-x. Epub 2022 Dec 10. PubMed PMID: 36495366; PubMed Central PMCID: PMC10060354.
  5. Moret M, Pachon Angona I, Cotos L, Yan S, Atz K, Brunner C, Baumgartner M, Grisoni F, Schneider G. Leveraging molecular structure and bioactivity with chemical language models for de novo drug design. Nat Commun. 2023 Jan 7;14(1):114. doi: 10.1038/s41467-022-35692-6. PubMed PMID: 36611029; PubMed Central PMCID: PMC9825622.
  6. Capdeville, C., Russo, L., Penton, D., Migliavacca, J., Zecevic, M., Gries, A., Neuhauss, S. C. F., Grotzer, M. A. & Baumgartner, M. Spatial proteomics finds CD155 and Endophilin-A1 as mediators of growth and invasion in medulloblastoma. Life Science Alliance 2022, 5(6), 1–18. https://doi.org/10.26508/lsa.202201380
  7. Migliavacca J, Züllig B, Capdeville C, Grotzer MA, Baumgartner M. Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion. Commun Biol. 2022 Aug 8;5(1):795. doi: 10.1038/s42003-022-03708-y. PubMed PMID: 35941177
  8. Schönholzer MT, Migliavacca J, Alvarez E, Santhana Kumar K, Neve A, Gries A, Ma M, Grotzer MA, Baumgartner M. Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion. Neoplasia. 2020 Oct;22(10):470-483. doi: 10.1016/j.neo.2020.07.006
  9. Dominique Bruns, Erik Gawehn, Karthiga Santhana Kumar, Petra Schneider, Martin Baumgartner & Gisbert Schneider. Identification of synthetic activators of cancer cell migration by hybrid deep learning ChemBioChem 2020, 21:500-507, doi 10.1002/cbic.201900346
  10. Neve A, Migliavacca J, Capdeville C, Schönholzer MT, Gries A, Ma M, Santhana Kumar K, Grotzer M, Baumgartner M. Crosstalk between SHH and FGFR Signaling Pathways Controls Tissue Invasion in Medulloblastoma. Cancers 2019,11(12). pii: E1985. doi: 10.3390/cancers11121985.
  11. Bruns D, Merk D, Santhana Kumar K, Baumgartner M, Schneider G. Synthetic Activators of Cell Migration Designed by Constructive Machine Learning. ChemistryOpen 2019 Oct 23;8(10):1303-1308. doi: 10.1002/open.201900222. eCollection 2019 Oct.
  12. Cruzeiro GAV, Lira RCP, de Almeida Magalhaes T, Scrideli CA, Valera ET, Baumgartner M, Tone LG. CTGF expression is indicative of better survival rates in patients with medulloblastoma. Cancer Gene Therapy 2019, doi: 10.1038/s41417-019-0100-3.
  13. Gustavo Alencastro Veiga Cruzeiro , Karina Bezerra Salomão, Carlos Alberto Oliveira de Biagi Jr, Martin Baumgartner, Dominik Sturm, Régia Caroline Peixoto Lira, Taciani de Almeida Magalhães, Mirella Baroni Milan, Vanessa da Silva Silveira, Fabiano Pinto Saggioro, Ricardo Santos de Oliveira, Paulo Henrique dos Santos Klinger, Ana Luiza Seidinger, José Andrés Yunes, Rosane Gomes de Paula Queiroz, Sueli Mieko Oba-Shinjo, Carlos Alberto Scrideli, Suely Marie Kazue Nagahashi, Luiz Gonzaga Tone and Elvis Terci Valera. A simplified approach using Taqman low-density array for medulloblastoma subgrouping. Acta Neuropathologica Communications 2019 7:33, doi.org/10.1186/s40478-019-0681-y
  14. Karthiga Santhana Kumar, Anuja Neve, Ana S. Guerreiro Stucklin, Claudia M. Kuzan-Fischer, Elisabeth J. Rushing, Michael D. Taylor, Dimitra Tripolitsioti, Lena Behrmann, Daniel Kirschenbaum, Michael A. Grotzer and Martin Baumgartner. TGF-ß determines the pro-migratory potential of bFGF signalling in medulloblastoma. Cell Rep. 2018, 23:3798-3812
  15. Dimitra Tripolitsioti, Karthiga Santhana Kumar, Anuja Neve, Jessica Migliavacca, Charles Capdeville, Elisabeth J. Rushing, Min Ma, Noriyuki Kijima, Ashish Sharma, Martin Pruschy, Scott McComb, Michael D. Taylor, Michael A. Grotzer & Martin Baumgartner.. MAP4K4 controlled integrin ß1 activation and c-Met endocytosis are associated with invasive behavior of medulloblastoma cells. Oncotarget 2018, May 1;9(33):23220-23236. doi: 10.18632/oncotarget.25294. eCollection 2018
  16. Anuja Neve1, Karthiga Santhana Kumar1, Dimitra Tripolitsioti1, Michael Grotzer1,2 and Martin Baumgartner. Investigation of brain tissue infiltration by medulloblastoma cells in an ex vivo model. Scientific Reports 2017, 7: 5297 | DOI:10.1038/s41598-017-05573-w

Reviews:

  1. Jovanovic D, Yan S, Baumgartner M. The molecular basis of the dichotomous functionality of MAP4K4 in proliferation and cell motility control in cancer. Front Oncol. 2022;12:1059513. doi: 10.3389/fonc.2022.1059513. eCollection 2022. Review. PubMed PMID: 36568222
  2. Tripolitsioti D, Grotzer MA, Baumgartner M. The Ser/Thr kinase MAP4K4 drives pro-metastatic cell functions. J Carcinog Mutagen 2017, 8:1 DOI: 10.4172/2157-2518.1000284
  3. Grotzer MA, Neve A, Baumgartner M. Dissecting brain tumor growth and metastasis in vitro and ex vivo. J Cancer Metastasis Treat 2016;2:149-62.
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